Anti-MET [7A2]

Description:

Recombinant monoclonal antibody to MET. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody 7A2.

Clone Name:

7A2

Published Application(s):

inhibition, SPR, ELISA

Published Species Reactivity:

Human

Products based on this clone:

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Ab03829-30.11 Anti-MET [7A2]
Human
scFv fragment (His)
ScFv
Purified
Ships in 5-6 weeks

Ab03829-23.0 Anti-MET [7A2]
Human
Rabbit IgG
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: P08581

Alternative Name(s) of Target: human HGF receptor; 084-G02; Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
Immunogen: The original antibody was selected by biopanning with a scFv phage library performed on solid-phase recombinant MET928.

Specificity: The antibody specifically binds to amino acid residues 568-741 of human MET.

Application Notes: The scFv fragment showed inhibition of HGF/SF induced migration of SKOV cells. In particular, the scFv fragment had an IC50 of 2.3 nM in the SKOV migration assay. The binding affinity of the scFv fragment to MET928 was measured by surface plasmon resonance (Kd= 3.6 nM). In a competition ELISA, binding of 2.5 nM of the Fab version of the antibody to a MET928-coated surface was inhibited by 15 μM and 5 μM NK1 (US20150147274A1).

Antibody first published in: DiCara et al. Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain Sci Rep. 2017 Aug 21;7(1):9000. PMID:
Note on publication: The original paper describes the generation and characterization of the antibody

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