United Kingdom (UK)
Recombinant monoclonal antibody to MPT32. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 13B12.
UniProt Accession Number of Target Protein: P9WIR7
Alternative Name(s) of Target: MTB MPT32; MPT-32; FAP-B; Rv1860; apa; Alanine and proline-rich secreted protein Apa; 45 kDa glycoprotein; 45/47 kDa antigen; Antigen MPT-32; Fibronectin attachment protein; Immunogenic protein MPT32; modD; MTCY359.13
Immunogen: The original antibody was generated by immunizing mice with recombinant Mycobacterium tuberculosis MPT32 protein.
Specificity: This antibody binds the MPT32 protein of Mycobacterium tuberculosis (MTB). MPT32 is a protein encoded by the Mtb Rv1980 gene, is one of the important secretory protein of the pathogenic bacteria, which is a candidate protein for the diagnosis of MTB infections. MPT32 has high immunogenicity and serves as a potent antigen in animals immunized with live bacteria, it induces a strong delayed-type hypersensitivity (DTH) in immunized animals. It mostly elicits a Th1 type of T-cell response in healthy humans; induces IFN-gamma production from CD4+ and CD8+ cells.
Application Notes: The binding characterization of this antibody towards Mycobacterium tuberculosis MPT32 protein was done using ELISA. This antibody can also recognize MTP32 protein from tuberculosis patient samples in a western blot (CN114591427).
Antibody first published in: PMID: