United Kingdom (UK)
Recombinant monoclonal antibody to Myelin basic protein. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma F23C6.
UniProt Accession Number of Target Protein: P02686
Alternative Name(s) of Target: MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein; F23
Immunogen: The original antibody was generated by hyperimmunization of BALB/c mice with a synthetic peptide comprising human MBP acetyl residues 1-9.
Specificity: This antibody binds human myelin basic protein (MBP), acetyl residues 1-9 (ASQKRPSQR). The MBP isoforms 4 and 14 along with PLP are most abundant protein components of the myelin membrane in the CNS. The smaller isoforms are believed to have an important role in remyelination of denuded axons in multiple sclerosis.
Application Notes: This antibody can be used for the detection of human MBP in a sample using ELISA. This antibody was found to react with human MBP peptides like acetyl 1-9, 1-14, and 1-44 (PMID: 1698857).
Antibody first published in:
Zhou et al. An idiotype shared by monoclonal antibodies to different peptides of human myelin basic protein. J Immunol. 1990 Oct 15;145(8):2554-60. PMID:1698857
Note on publication:
Describes the generation of antibody against human myelin basic protein and describes use of complementary peptide to human MBP peptide 1-9 to raise murine mAb with anti-Id activity.