United Kingdom (UK)
Recombinant monoclonal antibody to NORE1A. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 10F10-C6-C6.
UniProt Accession Number of Target Protein: Q8WWW0
Alternative Name(s) of Target: Ras association domain-containing protein 5; New ras effector 1; Regulator for cell adhesion and polarization enriched in lymphoid tissues; RAPL
Immunogen: The original antibody was generated by immunizing mice against amino acids 119-416 of human NORE1A.
Specificity: The antibody reacts with NORE1A epitope located within amino acids 119-191 of the human NORE1A protein, a unique sequence in the NORE1A splice form.
Application Notes: This antibody has been used to specifically bind NORE1A in Western blots (Kuznetsov et al, 2008; pmid:19098985); it detected NORE1A in human HBEC3-KT cells (Moshnikova et al, 2006; pmid:16421102). Immunofluorescence was performed on human bronchial epithelial cells (HBEC3-KT or HBEC3-KTR) using this antibody (Moshnikova et al, 2006; pmid:16421102).
Antibody first published in:
Moshnikova et al. The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway J Biol Chem. 2006 Mar 24;281(12):8143-52. PMID:16421102
Note on publication:
The article describes the generation and characterization of the antibody.