Anti-Notch 1 [N248A]

Description:

Recombinant monoclonal antibody to Notch 1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma N248A.

Clone Name:

N248A

Published Application(s):

Block, ELISA

Published Species Reactivity:

Human

Products based on this clone:

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Ab02406-23.0 Anti-Notch 1 [N248A]
Human
Rabbit IgG
Purified
Ships in 5-6 weeks

Ab02406-1.1 Anti-Notch 1 [N248A]
Human
Mouse IgG1
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: P46531

Alternative Name(s) of Target: Notch1; hN1; TAN-1; Neurogenic locus notch homolog protein 1; Translocation-associated notch protein TAN-1
Immunogen: The original antibody was generated by immunizing BALB/c mice with recombinant notch 1 fusion protein as immunogen. The fusion protein contained N-terminal leader peptide, EGF-like repeats 35 to 36, NRR (including Lin A, B and C domains and the HD domain) and a small portion of intracellular sequence.

Specificity: This antibody binds to notch 1 at two distinct sets of epitopes, one in Lin-A domain and other in HD-C domain (aa 1705- 1710), causing the notch 1 to be locked down in the silent conformation, and thus preventing the receptor from being activated by its ligands.

Application Notes: This antagonist antibody binds notch 1 with an affinity of Kd= 0.33 nM. The binding epitopes of Notch 1 antibody was analyzed by domain swap and ELISA binding assays. mAb N248A inhibits both T-cell acute lymphoblastic leukemia (T-ALL) and breast cancer cell growth in cell culture. N248A also inhibits T-cell lymphoblastic leukemia in murine xenograft tumor model (WO2012080891).

Antibody first published in: WO2012080891 PMID:

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