United Kingdom (UK)
Recombinant monoclonal antibody to Receptor tyrosine-protein kinase erbB-3. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from phage display BCD090-M2.
UniProt Accession Number of Target Protein: P21860
Alternative Name(s) of Target: HER3; Proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; erbB3
Immunogen: The sdAb was selected from a Llama-derived phage antibody library.
Specificity: BCD090-M2 recognises erbB3, a receptor tyrosine kinase. The overexpression of erbB3 in breast cancers is associated with reduced survival in patients.
Application Notes: The crystal structure of BCD090-M2 has been obtained (Eliseev et al, 2018). SPR indicates the equilibrium dissociation constant for BCD090-M2 bound to immobilised erbB3 is 1 μm (Eliseev et al, 2018).
Antibody first published in:
Eliseev et al, 2018. Crystal structures of a llama VHH antibody BCD090-M2 targeting human ErbB3 receptor F1000Research 2018, 7:57 PMID:
Note on publication:
Describes the purification of BCD090-M2 from the phage antibody library and its characterisation through SPR and crystallography.