United Kingdom (UK)
Recombinant monoclonal antibody to TGF beta1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody SL15S.
UniProt Accession Number of Target Protein: P01137
Alternative Name(s) of Target: TGFβ1; CAT-191; Kylie scFv; TGFB1, TGFB, Transforming growth factor beta-1, TGF-beta-1; Transforming growth factor beta-1 proprotein
Immunogen: The original antibody was generated by panning a human phage antibody library against TGF beta1.
Specificity: The antibody is specific for TGFβ2. It does not cross-react with TGFβ2 or TGFβ3.
Application Notes: The specificity of the original format of the antibody was confirmed by ELISA analysis. The ability of the scFv fragment to recognise TGFβ1 and neutralise binding of TGFβ1 to A549 cells was measured in the radioreceptor assay. The scFv fragment was a highly potent, neutralising antibody for TGFβ1, with IC50 values in the range 0.03 to 0 1 nM. In particular, the scFv fragment could neutralise active, but not latent, TGFβ1 (US7151169B2).
Antibody first published in: PMID: