United Kingdom (UK)
Recombinant monoclonal antibody to ULBP4. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 6E6.
UniProt Accession Number of Target Protein: Q8TD07
Alternative Name(s) of Target: NKG2DL4; Retinoic acid early transcript 1E; Lymphocyte effector toxicity activation ligand; NKG2D ligand 4; N2DL-4; RAE-1-like transcript 4; UL16-binding protein 4; ULBP-4
Immunogen: This antibodhy was raised against purified human ULBP.
Specificity: This antibody recognizes human ULBP4 which binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Application Notes: This antibody is recommended for the detection and analysis of human ULBP4. It has been successfully used in the identification of ULBP4 in flow cytometry, western blot and immunofluorescence. The antibody could detect ULBP4 surface expression on EBV-infected cells and on placental exosomes by flow cytometry (Zöller et al., 2018; PMID: 29651291 and Hedlund et al., 2009; PMID: 19542445).
Antibody first published in:
Vankayalapati et al. Role of NK cell-activating receptors and their ligands in the lysis of mononuclear phagocytes infected with an intracellular bacterium J Immunol. 2005 Oct 1;175(7):4611-7. doi: 10.4049/jimmunol.175.7.4611. PMID:16177106
Note on publication:
This paper describes the use of the anti-ULBP4 antibody.