United Kingdom (UK)
Recombinant monoclonal antibody to gp120. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody Clone 201.
UniProt Accession Number of Target Protein: P08810
Alternative Name(s) of Target: Surface protein gp120; SU; Glycoprotein 120; Envelope glycoprotein gp160; Env polyprotein; 201
Immunogen: An antibody phage display library was constructed from RNA extracted from lymph node cells of a simian immunodeficiency virus (SIV)-infected long-term-nonprogressor macaque. The original antibody was isolated by selection of the library against SIV monomeric gp120.
Specificity: The antibody is specific for gp120.
Application Notes: The specificity of the original format of the antibody was confirmed by ELISA analysis. The antibody demonstrated neutralizing activity against the homologous molecularly cloned virus SIVsmH4 and the homologous virus SIVsmB670 (Glamann et al., 1998; PMID: 9420262).
Antibody first published in:
Glamann et al. Simian immunodeficiency virus (SIV) envelope-specific Fabs with high-level homologous neutralizing activity: recovery from a long-term-nonprogressor SIV-infected macaque. J Virol. 1998 Jan;72(1):585-92. PMID:9420262
Note on publication:
The original paper describes the generation and characterization of the antibody