Anti-gp41 [A7]

Description:

Recombinant monoclonal antibody to gp41. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody A7.

Clone Name:

Published Application(s):

in vitro neutralization, ELISA

Published Species Reactivity:

HIV-1

Products based on this clone:

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Ab03525-23.0 Anti-gp41 [A7]
HIV-1
Rabbit IgG
Purified
Ships in 5-6 weeks

Ab03525-30.11 Anti-gp41 [A7]
HIV-1
scFv fragment (His)
ScFv
Purified
Ships in 5-6 weeks

Alternative Name(s) of Target: Envelope glycoprotein GP41; transmembrane protein gp41
Immunogen: A phage immune library generated from a long-term non-progressors with HIV neutralizing antibodies in his plasma. The phage library was screened on recombinant soluble gp140 envelope (Env) proteins and the antibody was isolated.

Specificity: The antibody is specific for gp41, and it binds to structural elements of the third variable loop V3.

Application Notes: The specificity of the original format of the antibody was confirmed by ELISA analysis. The antibody showed neutralizing activity against a panel of standardized Tier 1 and Tier 2 HIV-1 pseudo virions on Tzm-bl cells (Trott et al., 2014; PMID:24828352).

Antibody first published in: Trott et al. Functional characterization of two scFv-Fc antibodies from an HIV controller selected on soluble HIV-1 Env complexes: a neutralizing V3- and a trimer-specific gp41 antibody PLoS One. 2014 May 14;9(5):e97478. PMID:24828352
Note on publication: The original paper describes the generation and characterization of the antibody.

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