United Kingdom (UK)
Recombinant monoclonal antibody to lambda chain. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma Mc24-1C6.
UniProt Accession Number of Target Protein: P0CG04
Alternative Name(s) of Target: Ig lambda chain C region MGC; Ig lambda-1 chain C region
Immunogen: The mouse version of this antibody was raised by immunizing a BALB/c mouse with purified human IgG.
Specificity: This antibody is specific for the lambda chain of human IgG. The lambda chain is a constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.
Application Notes: To characterize newly generated antibodies, flow cytometry was performed on tumor cells incubated with the new antibodies using the mouse version of this antibody to stain the antibodies (Suárez et al, 2004; pmid:15183930).
Antibody first published in:
Suárez et al. Human monoclonal antibodies produced in transgenic BABkappa,lambda mice recognising idiotypic immunoglobulins of human lymphoma cells Mol Immunol. 2004 Jul;41(5):519-26. PMID:15183930
Note on publication:
Human monoclonal anti-human Id-IgM antibodies were generated in mice and characterized for therapy of patients with a B cell malignancies.