United Kingdom (UK)
Recombinant monoclonal antibody to virus particles. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody H10.
Alternative Name(s) of Target: Venezuelan equine encephalomyelitis virus;
Immunogen: The phage display library expressing single-chain antibodies (scFv) was produced from a hybridoma cell line. The library was panned against VEE virus to select for specific scFvs.
Specificity: The antibody is specific for VEEV. The antibody detects the subtype I strains TC83, TRD, 3880, P676, subtype III strain Mucambo, and subtype V strain Cabassou. The antibody does not cross-react with BHK21, EEE (Eastern equine encephalitis), WEE (Western equine encephalitis), and SLE (St. Louis encephalitis).
Application Notes: The specificity of the original format of the antibody was confirmed by ELISA analysis (Duggan et al, 2001; pmid:11572636).
Antibody first published in:
Duggan et al. Isolation of single-chain antibody fragments against Venezuelan equine encephalomyelitis virus from two different immune sources Viral Immunol. 2001;14(3):263-73. PMID:11572636
Note on publication:
The paper describes the generation and characterization of the antibodiy.