United Kingdom (UK)
Recombinant monoclonal antibody to Alpha Dystroglycan. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 1G12.
UniProt Accession Number of Target Protein: Q62165
Alternative Name(s) of Target: Dystroglycan 1; Dag1; αDG; Alpha-DG; α-DAG; ALPHA DAG; Dystroglycan; Dystrophin-associated glycoprotein 1; A-Dystroglycan; A Dystroglycan; Alpha-dystroglycan; α dystroglycan; α-dystroglycan; 2-1G12-1-26
Immunogen: The original antibody was generated by immunizing BALB/c mice with recombinant human α-distroglycan.
Specificity: This antibody specifically binds glycerol phosphate modifying group of human alpha dystroglycan. Alpha-dystroglycan (αDG) is an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. It is also a receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells and a receptor for laminin LAMA5. Defective glycosylation of alpha-dystroglycan is a biological marker for muscular dystrophy-dystroglycanopathy type A (MDDGA1), Walker-Warburg syndrome (WWS), muscle-eye-brain disease (MEB) and Fushan congenital muscle malnutrition (FCMD).
Application Notes: The binding characterization of this antibody towards glycerol phosphate modifying group of alpha dystroglycan was done using ELISA. This antibody can recognize glycerol phosphate modifying group of alpha dystroglycan in an western blot and flow cytometric assay. This antibody can also be used for the immunofluorescence staining of colon cancer tissue (JP2022060048).
Antibody first published in: PMID: