Anti-Angiotensin II [KAA8]

Name: Anti-Angiotensin II [KAA8]
SKU: Ab01568
Availability: InStock

Description:

Recombinant monoclonal antibody to Angiotensin II. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma KAA8.

Clone Name:

KAA8

Published Application(s):

Published Species Reactivity:

Rat, Human

Products based on this clone:

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Ab01568-1.1 Anti-Angiotensin II [KAA8]
Rat, Human
Mouse IgG1
Purified
In Stock

Ab01568-23.0 Anti-Angiotensin II [KAA8]
Rat, Human
Rabbit IgG
Purified
In Stock

UniProt Accession Number of Target Protein: P01019

Alternative Name(s) of Target: octapeptide hormone angiotensin II; AII
Immunogen: Angiotensin II

Application Notes: Angiotensin II is a potent regulator of blood pressure, body fluid and electrolyte homeostasis. It acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.

Antibody first published in: Mitchell,T.J. and Reilly,T.M. Amino acid sequence determination of three monoclonal antibodies to angiotensin II Pept. Res. 3 (6), 277-281 (1990) PMID:2134072
Note on publication: Describes the generation of anti-antgiotensin II antibodies.

Western blot on human plasma lysate. Using Ab01568-23.0. Click on image for more details.

Western Blot using anti-Angiotensin II antibody KAA8 (Ab01568) Human plasma lysates (35µg protein in RIPA buffer) were resolved on a SDS PAGE gel and blots were probed with the chimeric rabbit version of KAA8 (Ab01568-23.0) at 0.1 µg/ml before detection using an anti-rabbit secondary antibody. A primary incubation of 1h was used and protein was detected by chemiluminescence.

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