Anti-Anti-platelet aggregation protein [8H7]

Description:

Recombinant monoclonal antibody to Anti-platelet aggregation protein. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 8H7.

Clone Name:

8H7

Published Application(s):

Blocking, ELISA

Published Species Reactivity:

Anopheles stephensi

Products based on this clone:

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Ab00433-1.1 Anti-Anti-platelet aggregation protein [8H7]
Anopheles stephensi
Mouse IgG1
Purified
Ships in 5-6 weeks

Ab00433-1.4 Anti-Anti-platelet aggregation protein [8H7]
Anopheles stephensi
Mouse IgG1
Fc Silent™
Purified
Ships in 5-6 weeks

Ab00433-23.0 Anti-Anti-platelet aggregation protein [8H7]
Anopheles stephensi
Rabbit IgG
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: Q7YT37

Alternative Name(s) of Target: Ansg-1; AAPP
Immunogen: Recombinant AAPP.

Specificity: This antibody binds specifically to the turn-region of AAPP.

Application Notes: This antibody binds specifically to Anopheles anti-platetelet protein (AAPP), which blocks platelet adhesion to collagen by binding directly to collagen and subsequently aggregating platelets. This antibody prevents AAPP binding to collagen.

Antibody first published in: Sugiyama et al. The crystal strucuture of the active doain of Anopheles anti-platelet protein, a powerful anti-coagulant, in complex with an antibody. Journal of Biological CHemistry 2015; 289(23):16303-16312 PMID:24764297
Note on publication: Describes the generation of an anti- anti-platelet protein antibody and subsequent crystallography.