Anti-Ca 19-9 [121SLE]

Name: Anti-Ca 19-9 [121SLE]
SKU: Ab04318
Availability: InStock

Description:

Recombinant monoclonal antibody to Ca 19-9. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 121SLE.

Clone Name:

121SLE

Published Application(s):

ICC, ELISA, FC, IHC

Published Species Reactivity:

Human

Products based on this clone:

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Ab04318-23.0 Anti-Ca 19-9 [121SLE]
Human
Rabbit IgG
Purified
Ships in 5-6 weeks

Ab04318-21.0 Anti-Ca 19-9 [121SLE]
Human
Mouse IgM
Purified
Ships in 5-6 weeks

Alternative Name(s) of Target: 121 SLE; sialyl Lewis a
Immunogen: The original antibody was raised by immunizing a mouse with ten precipitin lines obtained after immunodiffusion using monoclonal antibody NS 19-9 and mucins isolated from an ovarian cyst of a OLe (a+b-) patient.

Specificity: This antibody is specific for CA19-9.

Application Notes: The original version of this antibody was used for immunohistochemistry on the normal gastrointestinal mucosa of Le-positive individuals (Herrero-Zabaleta et al., 1987; PMID:2444292), and on endometrial tissue specimens obtained in different phases of the menstrual cycle (Hey and Aplin., 1996; PMID:8910004). This antibody was used for an ELISA on carbohydrate proteins (Manimala et al., 2007; PMID:17483136), and on MUC1 samples (Hey and Aplin., 1996; PMID:8910004). Furthermore this antibody was used for immunocytochemistry on HT 29 tumour cells (Köhler et al., 2009; PMID:20010946). The original version of this antibody was used for flow cytometry on ovarian cancer cell line SW626 and SCLC cell line DMS79 (Ragupathi et al., 2009; PMID:19190907).

Antibody first published in: Herrero-Zabaleta et al. Monoclonal antibody against sialylated Lewis(a) antigen Bull Cancer. 1987;74(4):387-96. PMID:2444292
Note on publication: The original paper isolated hybridoma cells, which secreted monoclonal antibody (MAb) 121 SLE.

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