Anti-CD11b [VHHCD11b]

Description:

Recombinant monoclonal antibody to CD11b. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma VHHCD11b.

Clone Name:

VHHCD11b

Published Application(s):

FC, IF

Published Species Reactivity:

Mouse

UniProt Accession Number of Target Protein: P05555

Alternative Name(s) of Target: CR3A; ITGAM; DC13; VHHDC13; Integrin alpha-M; CR-3 alpha chain; CD11 antigen-like family member B; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor
Immunogen: The original antibody was originated by immunizing a camel with recombinant DC11b.

Specificity: The antibody is specific for CD11b.

Application Notes: The original format of the antibody specifically bound to CD11b+ cells in lymph nodes and spleen by two-photon microscopy and flow cytometry analysis. ¹⁸F-labelled antibody was used for noninvasive imaging of CD11b+ cells, both in normal and in tumor-bearing mice (Rashidian et al., 2015; PMID: 25902531). The antibody was conjugated to an H-2Db -restricted immunodominant E7 epitope (an HPV tumor antigen peptide) for treatment of HPV induced cancer (Woodham et al., 2018; PMID: 29792298).

Antibody first published in: Rashidian et al. Noninvasive imaging of immune responses Proc Natl Acad Sci U S A. 2015 May 12;112(19):6146-51. doi: 10.1073/pnas.1502609112. Epub 2015 Apr 20. PMID:25902531
Note on publication: The original paper describes the generation and characterization of the antibody.

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