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- Ab04086-10.3 Anti-CD133 [2C3]
- Human
- Human IgG1
- Fc Silent™
- Purified
- Ships in 5-6 weeks
- Ab04086-10.0 Anti-CD133 [2C3]
- Human
- Human IgG1
- Purified
- Ships in 5-6 weeks
- Ab04086-23.0 Anti-CD133 [2C3]
- Human
- Rabbit IgG
- Purified
- Ships in 5-6 weeks
Recombinant monoclonal antibody to CD133. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody 2C3.
UniProt Accession Number of Target Protein: O43490
Alternative Name(s) of Target: Prominin-1; Antigen AC133; Prominin-like protein 1
Immunogen: The original antibody was generated by screening a natural nanobody phage display library and panning against human CD133.
Specificity: The antibody is specific for CD133. CD133 is a cell surface glycoprotein molecule mainly localized to the bulge of the cytoplasmic membrane and is involved in the organization of the membrane. CD133 is often used as a marker for tumor stem cell isolation and identification
Application Notes: The specificity of the antibody was confirmed by ELISA analysis. This antibody was used for detection of CD133 expressed on CHO cells by flow cytometry. The antibody human IgG1 Fc fusion protein was constructed and used for detection of CD133 expressed on HT29, HCT116 and Caco-2 cells. The antibody drug conjugate obtained by coupling 2C3-hFc with DM1, showed cytotoxic activity on HT29, HCT116 and Caco-2 cells (CN113480651B).
Antibody first published in: PMID: