Anti-CD142 [10H10 (TF9-10H10)]

Description:

Recombinant monoclonal antibody to CD142. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 10H10 (TF9-10H10).

Clone Name:

10H10 (TF9-10H10)

Published Application(s):

ELISA, IF, IHC

Published Species Reactivity:

Human

5

Products based on this clone:

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Ab02351-23.0 Anti-CD142 [10H10 (TF9-10H10)]
Human
Rabbit IgG
Purified
Ships in 4-5 weeks

Ab02351-10.0 Anti-CD142 [10H10 (TF9-10H10)]
Human
Human IgG1
Purified
Ships in 4-5 weeks

Ab02351-10.3 Anti-CD142 [10H10 (TF9-10H10)]
Human
Human IgG1
Fc Silent™
Purified
Ships in 4-5 weeks

Ab02351-1.1 Anti-CD142 [10H10 (TF9-10H10)]
Human
Mouse IgG1
Purified
Ships in 4-5 weeks

Ab02351-1.4 Anti-CD142 [10H10 (TF9-10H10)]
Human
Mouse IgG1
Fc Silent™
Purified
Ships in 4-5 weeks

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UniProt Accession Number of Target Protein: P13726

Alternative Name(s) of Target: TF; F3; Tissue factor; Coagulation factor III; Thromboplastin
Immunogen: The original antibody was generated by subcutaneously immunizing a mouse with denatured human TF protein in R-700 adjuvant.

Specificity: This antibody binds the human tissue factor heavy chain protein (huTFh) and specifically binds huTFh polypeptide p1-30.

Application Notes: Tissue factor (TF), one of the cell-surface initiators of blood coagulation and has been identified as a critical controlling molecule in hemostasis, thrombosis and inflammation. This antibody is recommended for detection of tissue factor in a blood sample. This is a non neutralizing antibody, which is capable of binding human tissue factor heavy chain protein but does not neutralize the ability of tissue factor to initiate coagulation. This antibody was used to study the interaction between factor VII and tissue factor in solution using ELISA (PMID: 1874730). This antibody is also reported to be used to target TF pathway as a possible treatment strategy for glioblastoma therapy (PMID: 23384223). This antibody was used to study expression of TF in human glioma using immunofluorescence staining for identification of TF in U251 glioma cell line, normal brain specimens, and glioma surgical specimens (PMID: 12135696). This antibody was also used in the detection of TF in normal and abnormal human mammary glands using immunohistochemistry (PMID: 1514249).

Antibody first published in: Morrissey et al. Monoclonal antibody analysis of purified and cell-associated tissue factor. Thromb Res. (1988); 52(3):247-61. PMID:3194899
Note on publication: Describes the study on interaction between factor VII and TF using a library of murine antibodies that have specificity for TF.