United Kingdom (UK)
Recombinant monoclonal antibody to CD19. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 1D3.
UniProt Accession Number of Target Protein: P25918
Alternative Name(s) of Target: B-lymphocyte antigen CD19; Differentiation antigen CD19
Specificity: The antibody is specific for mouse CD19.
Application Notes: The scFv fragment of the antibody was employed in the generation of a chimeric antigen receptor (CAR) which bound to CD19. Mice were administered mouse CAR-expressing cells or control cells. Anti-muCD19 CAR-T mice exhibited elevated serum IL-6 levels on day 2 after CAR-T administration, with a decrease at day 5, compared to control mice that exhibited very low or no increase in serum IL-6 levels. A20 tumor bearing mice were administered CPA and anti -mouse CD 19 CAR-T cells and evaluated for various parameters. Animals treated with CPA and anti-mouse CD 19 CAR-T cells were observed to have elevated levels of serum cytokines, as compared to controls (EP3644721A1).
Antibody first published in: PMID: