Anti-CD257 (BAFF) [Nanobody 52]

Description:

Recombinant monoclonal antibody to CD257 (BAFF). Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the alpaca peripheral blood cells Nanobody 52.

Clone Name:

Nanobody 52

Published Application(s):

Block, ELISA

Published Species Reactivity:

Human

UniProt Accession Number of Target Protein: Q9Y275

Alternative Name(s) of Target: BLyS; TNFSF13B; TALL-1; TNFSF20; ZTNF4; Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; B-cell-activating factor; Dendritic cell-derived TNF-like molecule; TNF and APOL-related leukocyte expressed ligand 1
Immunogen: The original antibody was generated by immunizing an alpaca with extracellular sequence of human BAFF.

Specificity: This antibody binds human BAFF protein. B-cell-activating factor (BAFF/CD257) is a cytokine belonging to the tumour-necrosis factor (TNF) family. This cytokine binds to TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFF-R. BAFF is a survival factor for B cells that controls B-cell maturation. It is also involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.

Application Notes: This VHH antibody binds human BLyS with a moderate binding affinity of Kd= 3.18E-06M. The inhibitory activity of this activity of this antibody to precent binding of BLyS to its receptors BCMA and TACI was evaluated using ELISA in a competitive inhibition assay. This antibody was also capable of inhibiting BLyS stimulated proliferation of Raji cells (CN104804091).

Antibody first published in: PMID:

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