United Kingdom (UK)
Recombinant monoclonal antibody to CD40. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 3B2.
UniProt Accession Number of Target Protein: P25942
Alternative Name(s) of Target: TNFRS5; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor CDw40; CD154R; 19-3B2
Immunogen: The original antibody was generated by immunizing mice with recombinant human CD40 protein.
Specificity: This antibody recognizes and binds human and primate CD40, but does not cross react with mouse CD40. CD40 acts as a receptor for TNFSF5/CD40LG. This protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
Application Notes: The reactivity of this antibody to human, Ganlamp monkey and mouse CD40 protein expressed on the surface of CHO cells was determined using flow cytometry. This antibody positively binds human and primate CD40 proteins and does not cross react with mouse CD40. The original mouse IgG antibody binds human CD40 with a binding affinity of kd= 6.13X10^(-10) M. The tumor inhibitory activity of this antibody was also tested in vivo in B-HCD40 mice injected with murine MC-38 cells (colon cancer cells). This antibody exhibited good tumor inhibitory effect (CN111763259).
Antibody first published in: PMID: