Anti-Collagen alpha-1(VII) chain [LH7.2]

Description:

Recombinant monoclonal antibody to Collagen alpha-1(VII) chain. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma LH7.2.

Clone Name:

LH7.2

Published Application(s):

WB, ELISA, IHC

Published Species Reactivity:

Bovine, Goat, Guinea Pig, Marmoset, Monkey, Pig, Sheep, Human

UniProt Accession Number of Target Protein: Q02388

Alternative Name(s) of Target: COL7A1; LC collagen; Long-chain collagen; collagen VII
Immunogen: The original antibody was raised by immunizing a mouse with 1% Nonidet P40 extract of trypsinized cultured human keratinocytes.

Specificity: This antibody is specific for amino acids 252 to 361 of Collagen alpha-1(VII) chain.

Application Notes: The original antibody was used for western blotting on overlapping recombinant type VII collagen fusion proteins and pepsinized human type VII (Lapiere et al., 1994; PMID:7530994), and on type VII collagen fusion proteins (Tanaka et al., 1994; PMID:7524608). Further this antibody was used for an ELISA on non-overlapping type VII collagen fusion proteins encompassing both non- collagenous amino- and carboxyl-terminal domains and the collagenous helical domain (Lapiere et al., 1994; PMID:7530994). This antibody was used for immunohistochemistry on normal adult human skin freshly obtained from two different sites (abdomen and arm) (Shimizu et al., 1990; PMID:2354110), on different human tumours (Wetzels et al., 1991; PMID:1867328), and on normal human tissue (Heagerty et al., 1986; PMID:3527251).

Antibody first published in: Heagerty et al. Identification of an epidermal basement membrane defect in recessive forms of dystrophic epidermolysis bullosa by LH 7:2 monoclonal antibody: use in diagnosis Br J Dermatol. 1986 Aug;115(2):125-31 PMID:3527251
Note on publication: Using indirect immunofluorescence the original paper found intense labelling with LH 7:2 at the epidermal basement membrane (EBM) of normal skin, and in skin samples from patients with simplex, junctional, dominantly inherited dystrophic and acquired forms of epidermolysis bullosa (EB), as well as bullous pemphigoid.

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