Anti-D-Dimer [MA-15C5]

Description:

Recombinant monoclonal antibody to D-Dimer. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma MA-15C5.

Clone Name:

MA-15C5

Published Application(s):

ELISA, Imaging

Published Species Reactivity:

Human

Products based on this clone:

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Ab03954-1.1 Anti-D-Dimer [MA-15C5]
Human
Mouse IgG1
Purified
Ships in 5-6 weeks

Ab03954-23.0 Anti-D-Dimer [MA-15C5]
Human
Rabbit IgG
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: P02671

Alternative Name(s) of Target: XDP; Fragment D-dimer; Fibrin degradation fragment; Fibrin degradation product; Fibrin
Immunogen: The original antibody was generated by immunizing BALB/c mice with purified fragment D-dimer from cross linked human fibrin.

Specificity: This antibody is directed against a neoantigenic determinant expressed on the human fragment D-dimer. D-dimer is a protein fragment (small piece) that's made when a blood clot dissolves in your body. At D-dimer test is done to determine if a person has any blood clotting disorder.

Application Notes: This antibody has a 1000 fold higher affinity for binding human fragment D-dimer than for human fibrinogen. It could effectively bind D-dimer from human plasma clots and can be used for thrombus imaging in an animal model in vivo (PMID: 2749602). This antibody has been used in an ELISA assay for the quantification of fragment-D dimer in plasma (PMID: 3127914).

Antibody first published in: Holvoet et al. Binding properties of monoclonal antibodies against human fragment D-dimer of cross-linked fibrin to human plasma clots in an in vivo model in rabbits. Thromb Haemost. 1989 Apr 25;61(2):307-13. PMID:2749602
Note on publication: Describes the generation of two antibodies against human fragment D-dimer and determines their binding properties in an in vivo rabbit model.

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