Anti-desmoglein-3 [PVA232]

Description:

Recombinant monoclonal antibody to desmoglein-3. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the EBV transformed human B cell clone PVA232.

Made with Antibody Sequences licensed from Humabs Biomed SA.

Clone Name:

PVA232

Published Application(s):

ELISA, IF

Published Species Reactivity:

Human

Products based on this clone:

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Ab00154-10.0 Anti-desmoglein-3 [PVA232]
Human
Human IgG1
Purified
Ships in 4-5 weeks

Ab00154-1.1 Anti-desmoglein-3 [PVA232]
Human
Mouse IgG1
Purified
In Stock

UniProt Accession Number of Target Protein: P32926

Alternative Name(s) of Target: Pemphigus Vulgaris Ag; 130 kDa pemphigus vulgaris antigen; PVA; Cadherin family member 6; DSG3; CDHF6
Immunogen: Made by immortalizing IgG-expressing B cells from Pemphigus vulgaris (PV) patients.

Specificity: This antibody specifically recognizes a conformational epitope in the EC5 domain of human desmoglein-3 (DSG). This antibody was isolated as a human IgG1 from a patient with mucocutaneous pemphigus vulgaris and uses the VH3-23*01, D3-3*01, JH6*02, VL3-15*01 and JL4*01. This antibody does not have in vitro and in vivo pathogenic activity, as assessed in a keratinocyte dissociation assay.

Antibody first published in: Di Zenzo,G. et al. Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface. J Clin Invest 122, 3781–3790 (2012). PMID:22996451
Note on publication: Describes the isolation and analysis of a panel of human antibodies from patients - including data on ELISA, IF and in vitro and in vivo pathogenic activity assays.