Anti-EGFR [ML66]

Description:

Recombinant monoclonal antibody to EGFR. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma ML66.

Clone Name:

ML66

Published Application(s):

in vivo, inhibition, FC

Published Species Reactivity:

Human

Products based on this clone:

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Ab03825-6.1 Anti-EGFR [ML66]
Human
Rat IgG1
Purified
Ships in 5-6 weeks

Ab03825-23.0 Anti-EGFR [ML66]
Human
Rabbit IgG
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: P00533

Alternative Name(s) of Target: ERBB; ERBB1; HER1; PIG61; mENA; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; epidermal growth factor receptor
Immunogen: The original antibody was generated by immunizing female rats with membrane prep of MDA-MB468 breast cancer cell line.

Specificity: The antibody is specific for EGFR.

Application Notes: The humanized version of the antibody exhibited strong specific binding to both human tumor cell lines and Vero cells by flow cytometry. This original and humanized version of the antibody were used for detection of EGFR expressed on MDA-MB468 cells by flow cytometry. The humanized version of the antibody induced NK cell mediated killing of target cells in a dose dependent manner. The chML66-antibody-maytansinoid conjugates significantly deleted the tumor growth in a tumor xenograft model using EGFR expressing KB cells implanted subcutaneously in SCID mice (US20160017053A1).

Antibody first published in: PMID:

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