Anti-env, Envelope glycoprotein gp160 [ITS090.03]

Description:

Recombinant monoclonal antibody to env, Envelope glycoprotein gp160. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma ITS090.03.

Clone Name:

ITS090.03

Published Application(s):

crystallography, in vitro, neutralization, ELISA

Published Species Reactivity:

Simian immunodeficiency virus

Product based on this clone:

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Ab04435-23.0 Anti-env, Envelope glycoprotein gp160 [ITS090.03]
Simian immunodeficiency virus
Rabbit IgG
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: E7CWP5

Alternative Name(s) of Target: ITS90.03; gp120; Glycoprotein 120; Surface protein gp120
Immunogen: The original antibody was raised by immunizing a rhesus macaque with the well-characterized neutralization-resistant SIVmac239 strain

Specificity: This antibody recognizes a highly glycosylated epitope on the gp120 core.

Application Notes: The original antibody was used for a virus neutralization assay on SIV Env pseudoviruses. This antibody shows its ability to neutralize this virus (Gorman et al., 2019; PMID:31586542). This antibody was used for an competitive ELISA on SIVmac239 SOSIP.664 (Zhao et al., 2022; PMID:36068229), and on SIVmac239 gp140 FT and SIVmac239 gp120 V1V2V3-deleted gp120 core proteins. The structure of the original antibody was determined using both electron microscopy and x-ray crystallography (Gorman et al., 2019; PMID:31586542) (Zhao et al., 2022; PMID:36068229).

Antibody first published in: Gorman et al. Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields Immunity. 2019 Oct 15;51(4):724-734.e4 PMID:31586542
Note on publication: The original paper reports the isolation, structure, and glycan interactions of antibody ITS90.03, a monoclonal antibody that completely neutralized the highly neutralization-resistant isolate, SIVmac239.

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