Anti-FGRI [M19B2]

Name: Anti-FGRI [M19B2]
SKU: Ab02531
Availability: InStock

Description:

Recombinant monoclonal antibody to FGRI. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma M19B2.

Clone Name:

M19B2

Published Application(s):

IP, RIA, WB, FC, IF, IHC

Published Species Reactivity:

Rat, Human

Products based on this clone:

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Ab02531-1.1 Anti-FGRI [M19B2]
Rat, Human
Mouse IgG1
Purified
Ships in 5-6 weeks

Ab02531-6.1 Anti-FGRI [M19B2]
Rat, Human
Rat IgG1
Purified
Ships in 5-6 weeks

Ab02531-10.0 Anti-FGRI [M19B2]
Rat, Human
Human IgG1
Purified
Ships in 5-6 weeks

Ab02531-10.3 Anti-FGRI [M19B2]
Rat, Human
Human IgG1
Fc Silent™
Purified
Ships in 5-6 weeks

Ab02531-23.0 Anti-FGRI [M19B2]
Rat, Human
Rabbit IgG
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: P11362

Alternative Name(s) of Target: Fibroblast growth factor receptor 1; FGFR-1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr; CD331
Immunogen: Balb/c mice were immunized with recombinant human FGF-R1a or with both recombinant human FGF-R1b and recombinant human FGF-R1a .

Specificity: This antibody is specific for the acidic box and heparin-binding domain. FGFR is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.

Application Notes: To characterize this antibody a western blot was preformed on sf9 cells transfected with baculovirus recombinantly expressing the full length FGF-R1 protein. Furthermore immunoprecipitation was preformed on the lysed sf9 cells transfected with baculovirus recombinantly expressing the full length FGF-R1 protein. And finally a radioimmunityassay was preformed with the mouse version of this antibody on I125-labeled complexes (Xu et al, 1992; pmid:1325449). During research on the localization and behaviour of the FGF-1 protein the murine version of this antibody was used to immunoprecipitate FGFR and a 40-kDa complex it is part of (Feng et al, 1995; pmid:9244177). To confirm that Klotho-expressing B cells could respond to FGF23, their expression of FGFR1 was assayed by flow cytometry and immunohistochemical staining. For this the mouse version of this antibody was used (Nakashima et al, 2016; pmid:28095739). fluorescence immunocytochemistry was preformed on brain slices or brain cells from FGF-2 mice and FGF-2 knock-out mice using the mouse version of this antibody. This was done to prove that nuclear FGFR1 and Nurr1 are expressed in the nuclei of developing TH-positive cells in the embryonic ventral midbrain (Baron et al, 2012; pmid:22514272). While investigating a method to establish functional and stable neovessel networks to increase plaque stability The murine version of this antibody was used for western blot on proteins extracted from rabbit aortas and cell lysates (Mao et al, 2019; pmid:31755222).

Antibody first published in: Xu et al. Expression and immunochemical analysis of rat and human fibroblast growth factor receptor (flg) isoforms J Biol Chem. 1992 Sep 5;267(25):17792-803. PMID:1325449
Note on publication: A panel of 16 isoform and domain-specific polyclonal and monoclonal antibodies was developed and characterized.

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