United Kingdom (UK)
Recombinant monoclonal antibody to Fumonisin B1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma DV9.
Alternative Name(s) of Target: FMB1; FB1; ChEBI:38221; CAS: 116355-83-0
Immunogen: The original antibody was generated by immunizing BALB/c mice with bovine serum albumin conjugated fumonisin B1 (FMB1-BSA).
Specificity: This antibody is specific for fumonisin B1. It does not react with other toxins like ochratoxin A, aflatoxin B1 and deoxynivalenol. Fumonisin B1 (FB1) is a mycotoxin produced by the various species of Fusarium fungus specifically, Fusarium verticillioides which commonly infects corn, wheat and other agricultural products. FB1 is neurotoxic, hepatotoxic, and nephrotoxic in animals, and it has been classified as a possible carcinogen to humans.
Application Notes: This antibody can be used to detect fumonisin B1 in a contaminated sample. This antibody reacts with fumonisin B1 in an ELISA assay. It was reported that the scFv version of this antibody showed 12 fold lower binding activity towards FMB(1)-BSA as compared to the parental whole IgG antibody (PMID: 19597742).
Antibody first published in:
Min et al. Production and characterization of monoclonal antibody and its recombinant single chain variable fragment specific for a food-born mycotoxin, fumonisin B1. Bioprocess Biosyst Eng. 2010 Jan;33(1):109-15. PMID:19597742
Note on publication:
Describes the generation and characterization of an anti-fumonisin B1 antibody.