Anti-Fusion glycoprotein F0 [17-HD9]

Name: Anti-Fusion glycoprotein F0 [17-HD9]
SKU: Ab04423
Availability: InStock

Description:

Recombinant monoclonal antibody to Fusion glycoprotein F0. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the rhesus macaque B-cell clone 17-HD9.

Clone Name:

17-HD9

Published Application(s):

neutralization, ELISA

Published Species Reactivity:

Human respiratory syncytial virus A

Product based on this clone:

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Ab04423-23.0 Anti-Fusion glycoprotein F0 [17-HD9]
Human respiratory syncytial virus A
Rabbit IgG
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: P03420

Alternative Name(s) of Target: F; Fusion glycoprotein F0; Protein F
Immunogen: The original antibody was raised by immunizing a Rhesus Macaque with the FFL scaffold (similar to the F protein from human respiratory syncytial virus A), and then using b cell sorting to isolate the epitope-specific antibody.

Specificity: This antibody is specific for Protein F of the Human respiratory syncytial virus A. The exact epitope is very similar to the one shown in PDB:3IXT.

Application Notes: The original antibody was used for an ELISA on respiratory syncytial virus protein F. Further a plaque reduction assay was performed on the respiratory syncytial virus subtype A2, this assay showed some neutralization of the virus (Correia et al., 2014; PMID:24499818).

Antibody first published in: Correia et al. Proof of principle for epitope-focused vaccine design Nature. 2014 Mar 13;507(7491):201-6. PMID:24499818
Note on publication: The original paper created a designed immunogen (FFL_01) used to vaccinate nonhuman primates, which induced antibodies (e.g., 17-HD9) that bound the RSV epitope in a manner that mimicked motavizumab.

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