Anti-IL23 (p19) [G23-8]

Name: Anti-IL23 (p19) [G23-8]
SKU: Ab03741
Availability: InStock

Description:

Recombinant monoclonal antibody to IL23 (p19). Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma G23-8.

Clone Name:

G23-8

Published Application(s):

functional assay, neutralize, ELISA

Published Species Reactivity:

Mouse

Products based on this clone:

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Ab03741-2.0 Anti-IL23 (p19) [G23-8]
Mouse
Mouse IgG2a
Purified
In Stock

Ab03741-2.3 Anti-IL23 (p19) [G23-8]
Mouse
Mouse IgG2a
Fc Silent™
Purified
Ships in 5-6 weeks

Ab03741-23.0 Anti-IL23 (p19) [G23-8]
Mouse
Rabbit IgG
Purified
Ships in 5-6 weeks

Ab03741-8.1 Anti-IL23 (p19) [G23-8]
Mouse
Rat IgG2b
Purified
Ships in 5-6 weeks

Ab03741-8.4 Anti-IL23 (p19) [G23-8]
Mouse
Rat IgG2b
Fc Silent™
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: Q9EQ14

Alternative Name(s) of Target: IL23A; IL-23p19; IL23p19; IL23-p19; IL-23p19; SGRF; Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19
Immunogen: The original antibody was generated by immunizing rats with recombinant mouse IL-23 heterodimer.

Specificity: This antibody binds p19 subunit of mouse interleukin-23 (IL-23). IL-23A associates with IL-12B to form IL-23 interleukin which is a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokine IL-17. Mouse IL-23 also induces strong proliferation of memory T cells. IL-23 is secreted by activated dendritic cells.

Application Notes: This antibody can neutralize the bioactivity of IL-23 with no effect on IL-12 p70 bioactivity. This antibody can be used for the detection of mouse IL-23 p19 in an ELISA (PMID: 18802055). This antibody was used in assay to determine the effect of anti-IL23p19 antibody on increase in IL-17 production after neutralization of IL-4 in T cells cultured with IL-4 DCs or with non transduced DCs (PMID: 17195211). This antibody was reported to inhibit lactic acid-induced enhancement of IL-17 production by OT-II mouse splenocytes that had been stimulated with the TLR ligand peptidoglycan (PGN) and bacillus Calmette-Gue´rin cell wall skeleton (BCG-CWS) (PMID: 18490716).

Antibody first published in: Sarkar et al. Interleukin-17 as a molecular target in immune-mediated arthritis: immunoregulatory properties of genetically modified murine dendritic cells that secrete interleukin-4. Arthritis Rheum. 2007 Jan; 56(1):89-100. PMID:17195211

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