Anti-Gamma Delta TCR [B1.1]

Description:

Recombinant monoclonal antibody to Gamma Delta TCR. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma B1.1.

Clone Name:

B1.1

Published Application(s):

functional assay, Block, FC, IF, IHC

Published Species Reactivity:

Human, Rhesus Monkey, Cynomolgus Monkey

4

Products based on this clone:

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Ab03991-23.0 Anti-Gamma Delta TCR [B1.1]
Human, Rhesus Monkey, Cynomolgus Monkey
Rabbit IgG
Purified
Ships in 5-6 weeks

Ab03991-10.0 Anti-Gamma Delta TCR [B1.1]
Human, Rhesus Monkey, Cynomolgus Monkey
Human IgG1
Purified
Ships in 5-6 weeks

Ab03991-10.3 Anti-Gamma Delta TCR [B1.1]
Human, Rhesus Monkey, Cynomolgus Monkey
Human IgG1
Fc Silent™
Purified
Ships in 5-6 weeks

Ab03991-1.1 Anti-Gamma Delta TCR [B1.1]
Human, Rhesus Monkey, Cynomolgus Monkey
Mouse IgG1
Purified
Ships in 5-6 weeks

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UniProt Accession Number of Target Protein: P04234; P09693

Alternative Name(s) of Target: TCR γδ; γδ TCR; TCR GD; GD TCR; TCRg/d; T-cell surface glycoprotein CD3 delta chain; CD3D; T3D; T-cell receptor T3 delta chain; T-cell surface glycoprotein CD3 gamma chain; CD3G; T-cell receptor T3 gamma chain; CD3g; T3G; B1
Immunogen: Antigen-specific T cell blasts to poly-18, a polypeptide antigen of defined sequence and conformation, were generated from lymph nodes of antigen primed BALB/cCr mice. These blasts were fused with the BW5147 thymoma to obtain anti-poly-18-reactive T cell hybridomas from which the original antibody was generated.

Specificity: This antibody is specific for the human TCR delta and gamma chains. The T-cell receptor (TCR) is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. On activation through antigen presenting cells (APCs), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. TCR part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.

Application Notes: This antibody can be used for the flow cytometric analysis of human peripheral blood cells (PMID: 12121897; 23447017; 25777993; 28223321). This antibody was used to block human γδ T cell receptor and prevent the human anti-porcine γδ T cell response (PMID: 11502983). This antibody was also used to block the γδ T cell receptors in in-vitro tumor-killing assays (PMID: 21633088). This antibody was used for the immunohistochemical analysis of frozen tissue samples of parapsoriasis, mycosis fungoides and inflammatory dermatoses (PMID: 21479436). This antibody was also used for the immunohistochemical and indirect immunofluorescence staining of γδ T cells in breast cancer and normal tissues (PMID: 23959855).

Antibody first published in: Fotedar et al. Fine specificity of antigen recognition by T cell hybridoma clones specific for poly-18: a synthetic polypeptide antigen of defined sequence and conformation. J Immunol. 1985 Nov;135(5):3028-33. PMID:2413110
Note on publication: Describes the epitope characterization of T cell hybridomas specific for Poly-18.