Anti-Genome polyprotein [anti-CVA16-14B10]

Description:

Recombinant monoclonal antibody to Genome polyprotein. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma anti-CVA16-14B10.

Clone Name:

anti-CVA16-14B10

Published Application(s):

in vitro, neutralization, ELISA

Published Species Reactivity:

Coxsackievirus A16 (strain Tainan/5079/98)

UniProt Accession Number of Target Protein: Q9QF31

Alternative Name(s) of Target: P1; 18A7
Immunogen: The original antibody was raised by immunizing a mouse with CVA16.

Specificity: This antibody is specific for the threefold plateau of the canyon of CVA16.

Application Notes: The original antibody was used for a neutralization assay against CVA16 in human rhabdomyosarcoma. Further an ELISA was performed on 16 strains of CVA16. The structure of this antibody was determined using cryo-EM (He et al., 2020; PMID:32027857).

Antibody first published in: He et al. Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16 Cell Host Microbe. 2020 Feb 12;27(2):249-261. PMID:32027857
Note on publication: The original paper identifies three CVA16-specific neutralizing monoclonal antibodies (nAbs) with therapeutic potential: 18A7, 14B10, and NA9D7.

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