Anti-Genome polyprotein [PVSP6A]

Description:

Recombinant monoclonal antibody to Genome polyprotein. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma PVSP6A.

Clone Name:

PVSP6A

Published Application(s):

in vitro, neutralization, SPR

Published Species Reactivity:

Poliovirus

UniProt Accession Number of Target Protein: P03300

Alternative Name(s) of Target: Capsid protein VP1; Capsid protein VP2; Poliovirus type 1
Immunogen: The original antibody was raised by immunizing a dromedary with poliovirus type 1 Sabin strain.

Specificity: This antibody is specific for Capsid proteins VP1 (GH loop, EF loop and C beta strand) and VP2 (EF loop) of the polio genome polyprotein.

Application Notes: The binding strength of the original antibody to poliovirus antigens was determined using surface plasmon resonance (Thys et al., 2011; PMID:21371506). The original antibody was used for a neutralization assay against three types of poliovirus. This antibody showed strong neutralization in type 1 polioviruses. The cytotoxicity of this antibody on HeLa cells was also evaluated. It showed no cytotoxicity (Thys et al., 2010; PMID:20566349). The effect of this antibody on virus entry and uncoating was determined. It showed change in the behavior of the polio particles (Schotte et al., 2014; PMID:24501405). The structure of this antibody was determined using cryo-EM (Strauss et al., 2016; PMID:26764003).

Antibody first published in: Thys et al. In vitro antiviral activity of single domain antibody fragments against poliovirus Antiviral Res. 2010 Aug;87(2):257-64 PMID:20566349
Note on publication: The original paper aimed to determine whether VHHs inhibit wild-type and vaccine strains of poliovirus type 1.

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