Anti-Ghrelin [5A1]

Description:

Recombinant monoclonal antibody to Ghrelin. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 5A1.

Clone Name:

5A1

Published Application(s):

in vivo, SPR

Published Species Reactivity:

Human

Product based on this clone:

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Ab03853-1.1 Anti-Ghrelin [5A1]
Human
Mouse IgG1
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: Q9UBU3

Alternative Name(s) of Target: GHRL; MTLRP; Appetite-regulating hormone; Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide; Protein M46

Specificity: The antibody recognises ghrelin. Ghrelin is a hormone produced by enteroendocrine cells of the gastrointestinal tract, especially the stomach and is often called a "hunger hormone" because it increases the drive to eat.

Application Notes: The kinetic constant of the humanized, affinity matured Fab version of the antibody was measured by KinExA (Kd= 1 pM). The binding affinity of the Fab fragment to Ghrelin was measured by surface plasmon resonance (Kd= 2 pM). Rats were injected with human ghrelin and their food consumption was measured. Results showed that if the humanized Fab version of the antibody was administrated, their food consumption was effectively reduced (US7479271).

Antibody first published in: PMID:

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