Anti-Glycoprotein B of HSV [Fd79]

Name: Anti-Glycoprotein B of HSV [Fd79]
SKU: Ab02069
Availability: InStock

Description:

Recombinant monoclonal antibody to Glycoprotein B of HSV. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma Fd79.

Clone Name:

Fd79

Published Application(s):

NTRL, FC, IF

Published Species Reactivity:

Herpes Simplex Virus

Products based on this clone:

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Ab02069-1.1 Anti-Glycoprotein B of HSV [Fd79]
Herpes Simplex Virus
Mouse IgG1
Purified
Ships in 4-5 weeks

Ab02069-23.0 Anti-Glycoprotein B of HSV [Fd79]
Herpes Simplex Virus
Rabbit IgG
Purified
Ships in 4-5 weeks

Ab02069-10.0 Anti-Glycoprotein B of HSV [Fd79]
Herpes Simplex Virus
Human IgG1
Purified
Ships in 4-5 weeks

Ab02069-10.3 Anti-Glycoprotein B of HSV [Fd79]
Herpes Simplex Virus
Human IgG1
Fc Silent™
Purified
In Stock

UniProt Accession Number of Target Protein: P10211

Alternative Name(s) of Target: gB; HSV gB; Herpes simplex virus; Envelope glycoprotein B; UL27
Immunogen: This antibody was raised against Herpes simplex virus.

Specificity: This antibody recognizes and binds a shared epitope of glycoprotein B (gB) of HSV1 and HSV2.

Application Notes: This antibody protected mice against encephalitis and death following ocular inoculation with the virus. Fd79 (anti-gB) prevented encephalitis even when immunization was delayed until 48 hours post-infection. It significantly reduced the severity of epithelial keratitis and lowered the frequency of persistent viral infection in an outbred mouse model. Murine Fd79 has been shown to neutralize HSV-1 in vitro without complement. Both humanized and murine Fd79 cause a 90% reduction of plaques at an antibody concentration of 7 nM (1 ug/ml) (PMID: 3010559, 3030642, 2838428). The binding of antibody to HSV-infected Vero cells was tested using fluorocytometry. Immunostaining was used to view Vero cell monolayers infected with HSV-1 and total cell lysis in the presence of Fd79. Humanized version of this antibody saw a two fold decrease in affinity (PMID: 1849279).

Antibody first published in: Koga et al. Studies on herpes simplex virus type 1 glycoproteins using monoclonal antibodies. Virology (1986); 151(2):385-9. PMID:3010559
Note on publication: Describes the synthesis and processing of glycoprotein B, C and D of herpes simplex virus and their characterization using monoclonal antibodies.