United Kingdom (UK)
Recombinant monoclonal antibody to Glycoprotein G. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma NAbC.
UniProt Accession Number of Target Protein: E3T3A7; P13180; A0A290D162
Alternative Name(s) of Target: CHPV; CHPV glycoprotein G; CHPV G protein; G-protein; surface glycoprotein
Immunogen: This antibody was generated against strain CIN0327 of the Chandipura virus (CHPV).
Specificity: This antibody binds the surface glycoprotein (G-protein) of Chandipura Virus (CHPV), a member of Rhabdoviridae. This virus is responsible for an explosive outbreak, with high mortality, in rural areas of India. It affects mostly children and is characterized by encephalitic illness or influenza-like illness and neurologic dysfunctions. It is transmitted by vectors such as mosquitoes, ticks and sand flies.
Application Notes: This antibody can neutralize prototype I653514 as well as the currently circulating strain 148974 of the Chandipura virus. This antibody can be used for the detection of CHPV in a sample using ELISA (PMID 30116984).
Antibody first published in:
Pavitrakar et al. Identification of a conserved neutralizing epitope in the G-protein of Chandipura virus. Arch Virol. 2018 Dec;163(12):3215-3223. PMID:30116984
Note on publication:
This paper compares the surface glycoprotein (G-protein) of Chandipura virus from prototype and recent outbreak strains using in silico tools and in vitro experiments.