Anti-gp120 [Y498]

Name: Anti-gp120 [Y498]
SKU: Ab03687
Availability: InStock

Description:

Recombinant monoclonal antibody to gp120. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody Y498.

Clone Name:

Y498

Published Application(s):

neutralization, SPR, ELISA

Published Species Reactivity:

HIV-1

Product based on this clone:

{{heading}}

Please Select

Ab03687-23.0 Anti-gp120 [Y498]
HIV-1
Rabbit IgG
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: P04578

Alternative Name(s) of Target: Glycoprotein 120; SU; surface protein gp120; env polyprotein; envelope glycoprotein gp160
Immunogen: A phage display Fab library was constructed using the PBMC samples of a CRF07_BC-infected subject. The antibody was selected by panning the library with a CRF07_BC (CN54)-derived rgp120 antigen.

Specificity: The antibody is specific for gp120. The conformational epitope of contains three antigenic sites on gp120, including the CD4 binding loop in C3, the β23 in C4 and the β24-α5 in C5.

Application Notes: The Fab fragment neutralized the R5 isolate SF162 and the X4 isolate HXB2 at a dose-dependent manner. The specificity of the Fab and IgG1 format of the antibody was confirmed by ELISA analysis. The binding affinity of the IgG1 antibody was measured by SPR assay, the antibody bound to CN54 rgp120 with a Kd value of 0.46 nM and bound to JRFL rgp120 with a Kd value at 0.86 nM. The antibody cross-reacted with diverse Env antigens and neutralized 30% of 70 tested HIV-1 isolates. The antibody could efficiently inhibit the binding of biotinylated sCD4 to rgp120 at a dose-dependent manner in competition ELISA (Sun et al., 2017; PMID :28968970).

Antibody first published in: Sun et al. Identification of a novel HIV-1-neutralizing antibody from a CRF07_BC-infected Chinese donor Oncotarget. 2017 Jun 21;8(38):63047-63063. PMID:28968970
Note on publication: The original paper describes the generation and characterization of the antibody.

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.

Necessary

Always Enabled

Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.

Cookie	Duration	Description
ASP.NET_SessionId	session	Issued by Microsoft's ASP.NET Application, this cookie stores session data during a user's website visit.
cookielawinfo-checkbox-advertisement	1 year	Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Advertisement" category .
cookielawinfo-checkbox-analytics	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional	11 months	The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy	11 months	The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.

Analytics

Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.

Cookie	Duration	Description
_dc_gtm_UA-49047364-1	1 minute	No description
_ga	2 years	The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors.
_gcl_au	3 months	Provided by Google Tag Manager to experiment advertisement efficiency of websites using their services.
_gid	1 day	Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously.
ai_session	30 minutes	This is a unique anonymous session identifier cookie set by Microsoft Application Insights software to gather statistical usage and telemetry data for apps built on the Azure cloud platform.
ai_user	1 year	A unique user identifier cookie, set by Microsoft Application Insights software, that enables counting of the number of users accessing the application over time.

Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.

Cookie	Duration	Description
_uetsid	1 day	Bing Ads sets this cookie to engage with a user that has previously visited the website.
_uetvid	1 year 24 days	Bing Ads sets this cookie to engage with a user that has previously visited the website.
MUID	1 year 24 days	Bing sets this cookie to recognize unique web browsers visiting Microsoft sites. This cookie is used for advertising, site analytics, and other operations.
test_cookie	15 minutes	The test_cookie is set by doubleclick.net and is used to determine if the user's browser supports cookies.