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- Ab03522-23.159 Anti-gp140 [VHH28]
- HIV-1
- Rabbit IgG-Fc fusion
- Purified
- Ships in 5-6 weeks
- Ab03522-1.159 Anti-gp140 [VHH28]
- HIV-1
- Mouse IgG1-Fc fusion
- Purified
- Ships in 5-6 weeks
Recombinant monoclonal antibody to gp140. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody VHH28.
Alternative Name(s) of Target: gp140 SOSIP
Immunogen: The original antibody was generated by immunizing dromedaries with the trimeric subtype C gp140 SOSIPs followed by antibody library construction and phage display-based selection.
Specificity: The antibody is specific for gp140 SOSIP of subtype C. The antibody cross-reacts with subtypes A and G.
Application Notes: The specificity of the original format of the antibody was confirmed by competition ELISA analysis. The structure of the antibody was determined. The antibody was able to neutralize subtype C, subtypes A and G (Koch et al. 2017; pmid:28827559)
Antibody first published in:
Koch et al. Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers Sci Rep. 2017 Aug 21;7(1):8390. PMID:28827559
Note on publication:
The original paper describes the generation and characterization of a set of antibodies obtained by phage display.