- {{heading}}
- Ab03521-23.159 Anti-gp140 [VHH5]
- HIV-1
- Rabbit IgG-Fc fusion
- Purified
- Ships in 5-6 weeks
- Ab03521-1.159 Anti-gp140 [VHH5]
- HIV-1
- Mouse IgG1-Fc fusion
- Purified
- Ships in 5-6 weeks
Recombinant monoclonal antibody to gp140. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody VHH5.
Alternative Name(s) of Target: gp140 SOSIP
Immunogen: The original antibody was generated by immunizing dromedaries with the trimeric subtype C gp140 SOSIPs followed by antibody library construction and phage display-based selection.
Specificity: The antibody is specific for gp140 SOSIP of subtype C.
Application Notes: The specificity of the original format of the antibody was confirmed by competition ELISA analysis. The structure of the antibody was determined. The antibody was able to neutralize subtype C of HIV (Koch et al. 2017; pmid:28827559).
Antibody first published in:
Koch et al. Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers Sci Rep. 2017 Aug 21;7(1):8390. PMID:28827559
Note on publication:
The original paper describes the generation and characterization of a set of antibodies obtained by phage display.