United Kingdom (UK)
Recombinant monoclonal antibody to HA. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the human B cell clone 641 I-9.
UniProt Accession Number of Target Protein: A7UPX0
Alternative Name(s) of Target: Hemagglutinin
Specificity: The antibody binds to the head of the hemagglutinin (HA) in the RBS region. HA is one of two glycoproteins on the virion surface and it mediates entry of the virus into a host cell by engaging its receptor, sialic acid. HA also catalyzes the merging of viral and cellular membranes necessary to establish infection.
Application Notes: The crystal structure of the antibody in complex with Hemagglutinin was determined. The neutralization activity of the antibody for H1 Solomon Islands/03/2006 wild-type or a virus with resistance mutation G189D was tested (IC50= 0,0018 and 0,0302 ug/ml). The specificity of the antibody was determined by ELISA (Schmidt et al., 2015; PMID: 25959776).
Antibody first published in:
Schmidt et al. Viral receptor-binding site antibodies with diverse germline origins. Cell. 2015 May 21;161(5):1026-1034. PMID:25959776
Note on publication:
The paper describes the generation, structure and characterization of the antibody.