Anti-Hairpin DNA [DNA-1]

Description:

Recombinant monoclonal antibody to Hairpin DNA. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma DNA-1.

Clone Name:

DNA-1

Published Application(s):

WB, ELISA

Published Species Reactivity:

Products based on this clone:

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Ab00415-1.1 Anti-Hairpin DNA [DNA-1]
Mouse IgG1
Purified
In Stock

Ab00415-1.4 Anti-Hairpin DNA [DNA-1]
Mouse IgG1
Fc Silent™
Purified
In Stock

Ab00415-23.0 Anti-Hairpin DNA [DNA-1]
Rabbit IgG
Purified
In Stock

Ab00415-23.3 Anti-Hairpin DNA [DNA-1]
Rabbit IgG
Fc Silent™
Purified
In Stock

Ab00415-24.1 Anti-Hairpin DNA [DNA-1]
Goat IgG
Purified
In Stock

Immunogen: Derived from bacteriophage display library of IgG fragments derived from the immunoglobulin repertoire of an autoimmune SLE-like MRL7lpr mouse.

Specificity: Binds to hairpin-ssDNA; the DNA-fragment-ligand used is 5′-d [CTG(CCTT)CAG]-3′.

Application Notes: This antibody binds to single-stranded hairpin DNA, which is a secondary structural feature of DNA relevant in replication, bacterial conjugation or viral infections.

Antibody first published in: Ou et al. Impact of DNA hairpin folding energetics on antibody-ssDNA association. Journal of Molecular Biology 2007; 374(4)1029-1040 PMID:18028946
Note on publication: Describes the generation of a monoclonal antibody against hairpin-DNA and subsequent crystallisation.