United Kingdom (UK)
Recombinant monoclonal antibody to Hantaan virus GP. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 3G1.
UniProt Accession Number of Target Protein: P08668
Alternative Name(s) of Target: HTNV; HTNV GP; HTNV envelop glycoprotein; Hantavirus; Envelopment polyprotein; scFv3G1; MAb3G1
Specificity: This antibody binds the envelop glycoprotein (GP) of the Hantaan virus (HTNV). Hantaan virus (HTNV) is the type of Hantavirus which are rodent-borne RNA viruses that belong to the Bunyaviridae family and can cause Hemorrhagic Fever with Renal Syndrome (HFRS), more commonly found in the Old World, and Hantavirus Pulmonary Syndrome (HPS), present mostly in the American continent. HPS is transmitted to humans by inhalation of virus-contaminated aerosols from rodent excreta.
Application Notes: This antibody can bind Hantaan virus (HNTV) GP in an ELISA. The binding of this antibody HTNV GP expressed on the cell membrane was determined using flow cytometry. This antibody can also recognize HNTV GP in a western blot. It was also reported that this antibody can be internalized into the cytoplasm of HTNV infected Vero E6 cells. This internalization was studied with the use of immunofluorescence staining (PMID: 20012277).
Antibody first published in:
Yang et al. Production and characterization of a recombinant single-chain antibody against Hantaan virus envelop glycoprotein. Appl Microbiol Biotechnol. 2010 Apr;86(4):1067-75. PMID:20012277
Note on publication:
Describes the generation and characterization of a recombinant scFv version of this antibody.