United Kingdom (UK)
Recombinant monoclonal antibody to HBV pre-S2 protein. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 1F6.
UniProt Accession Number of Target Protein: Q9DUH0
Alternative Name(s) of Target: PreS2; Large envelope protein; L glycoprotein; L-HBsAg; Large S protein; Large surface protein; Major surface antigen
Immunogen: The original antibody was generated by immunizing mice with purified HBsAg containing pre-S1 and pre-S2 proteins.
Specificity: This antibody binds an epitope 'DPRVRGLYF' (amino acids 131-141) of the pre-S2 region of the hepatitis B virus. Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). It can cause chronic infection and puts people at high risk of death from cirrhosis and liver cancer.
Application Notes: The binding reactivity and affinity of this antibody towards HBV pre-S2 protein was determined using ELISA. The original mouse IgG1 version of this antibody was reported to bind pre-S2 protein of HBV with a binding affinity of Kd= 1.2 nM (PMID: 10509818).
Antibody first published in:
Küttner et al. Characterization of neutralizing anti-pre-S1 and anti-pre-S2 (HBV) monoclonal antibodies and their fragments. Mol Immunol. 1999 Jul;36(10):669-83. PMID:10509818
Note on publication:
Describes the generation and epitope characterization of two antibodies against pre-S1 and pre-S2 region of hepatitis B virus.