Anti-HIV-1 GP120 [VRC03]

Name: Anti-HIV-1 GP120 [VRC03]
SKU: Ab02806
Availability: InStock

Description:

Recombinant monoclonal antibody to HIV-1 GP120. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the human B cell clone VRC03.

Clone Name:

VRC03

Published Application(s):

neutralize, SPR, ELISA

Published Species Reactivity:

HIV-1

Products based on this clone:

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Ab02806-23.0 Anti-HIV-1 GP120 [VRC03]
HIV-1
Rabbit IgG
Purified
Ships in 4-5 weeks

Ab02806-10.0 Anti-HIV-1 GP120 [VRC03]
HIV-1
Human IgG1
Purified
In Stock

UniProt Accession Number of Target Protein: P35961

Alternative Name(s) of Target: Glycoprotein 120; SU; surface protein gp120; env polyprotein; envelope glycoprotein gp16
Immunogen: The original antibody was generated from human B cells obtained from an HIV infected donor.

Specificity: This antibody binds CD4 binding site of the HIV-1 GP120.

Application Notes: The binding profile of this antibody towards HIV-1 GP120 was studied using ELISA and surface plasmon resonance. The original VRC03 IgG1 antibody, successfully neutralizes over 50% of current circulating HIV-1 isolates. (Mascola et al., US8637036). This antibody was reported to bind the resurfaced stabilized core 3 (RSC3) of the mutated HIV-1 envelop glycoprotein that is also capable of binding CD4. The original IgG1 version of this antibody has a binding affinity of KD = 7.31 × 10–8 M. (PMID: 20616233). VRC03 was found to potently inhibit entry into CD4+ T cells of HIV isolated from the latent viral reservoir of infected individuals whose plasma viremia was well controlled by antiretroviral therapy (ART) (PMID: 25157148).

Antibody first published in: Wu et al. Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1. Science. 2010 Aug 13; 329(5993): 856–861. PMID:20616233
Note on publication: Describes the generation and isolation of CD4-binding site specific neutralizing antibodies from the sera of an HIV-1–infected donor.

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