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- Ab02347-23.0 Anti-HIV-1 GP120 [YZ23]
- HIV-1
- Rabbit IgG
- Purified
- Ships in 5-6 weeks
- Ab02347-2.0 Anti-HIV-1 GP120 [YZ23]
- HIV-1
- Mouse IgG2a
- Purified
- Ships in 5-6 weeks
Recombinant monoclonal antibody to HIV-1 GP120. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma YZ23.
UniProt Accession Number of Target Protein: P04578
Alternative Name(s) of Target: Glycoprotein 120; SU; surface protein gp120; env polyprotein; envelope glycoprotein gp16
Immunogen: The original antibody was generated by immunizing mice with an electrophilic HIV-1 gp120 covalently reactive analog (E-gp120).
Specificity: This antibody binds irreversibly with GP120 of the HIV-1 virus. This antibody shows specific binary reactivity for peptides containing amino acid residues 292–306 and 421– 433 of the gp120 protein.
Application Notes: This antibody is capable of irreversibly binding both HIV-1 GP120 and its covalently reactive analogue in an ELISA. (PMID: 12665517). This antibody neutralized the infection of peripheral blood mononuclear cells by a primary HIV-1 isolate belonging to clade C (strain ZA009) (PMID: 16838382). It is also capable of neutralizing genetically diverse HIV strains like 92RW008, PAVO, SF162, 92BR021, QHO692, 92BR020, 98BR004, Du172, Du422, 97ZA009 and 98TZ017 (PMID: 19726674).
Antibody first published in:
Paul et al. Specific HIV gp120-cleaving antibodies induced by covalently reactive analog of gp120. J Biol Chem. (2003); 278(22):20429-35. PMID:12665517
Note on publication:
Describes the generation of HIV-1 GP120 cleaving antibodies by using its covalently reactive analogue for immunizations.