United Kingdom (UK)
Recombinant monoclonal antibody to Human Rhinovirus 14. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma Fab17-IA.
UniProt Accession Number of Target Protein: P03303
Alternative Name(s) of Target: HRV14; VP1; Genome polyprotein; Capsid protein VP1; P1D; Virion protein 1
Immunogen: The original antibody was generated from a mouse immunizied with human rhinovirus 14.
Specificity: This antibody binds the NIm-IA site of the human rhinovirus 14 between residues D1091 and E1095.
Application Notes: This neutralizing antibody binds NIm-IA site of the human rhinovirus 14. The original IgG2a version of this antibody binds wild type HRV14 with an affinity of ~180nM and can also binds site specific mutants of HRV14 (PMID: 7679742). This antibody has be widely used in structural studies relating to human rhinovirus 14 (PMID: 7679742, 8027997, 9573224 and Smith et al, 1995).
Antibody first published in:
Smith et al. Structure of human rhinovirus complexed with Fab fragments from a neutralizing antibody. J Virol. 1993 Mar; 67(3):1148-58. PMID:7679742
Note on publication:
Describes the structure of Fab17-IA when complexed with human rhinovirus.