Anti-IgE [rhuMAb-E25 (Omalizumab)]

Description:

Recombinant monoclonal antibody to IgE. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma rhuMAb-E25 (Omalizumab).

Clone Name:

rhuMAb-E25 (Omalizumab)

Published Application(s):

Blocking, in vitro, in vivo, therapeutic

Published Species Reactivity:

Human

Product based on this clone:

{{heading}}

Please Select

Ab00874-10.17 Anti-IgE [rhuMAb-E25 (Omalizumab)]
Human
Human IgG1
-
In Stock

UniProt Accession Number of Target Protein: P12319

Alternative Name(s) of Target: Immunoglobulin epsilon; FcERI; FCER1; FCϵRI; FCϵR1; Fc-epsilon RI-alpha; IgE Fc receptor subunit alpha
Immunogen: The original antibody is the recombinant humanized version of MaE11, a murine anti-IgE monoclonal antibody, constructed from the complementarity determining regions of MaE11 and a human IgG1 frame.

Specificity: This antibody is specific for the Fc region of human IgE.

Application Notes: This antibody has two potential binding sites on IgE (one for each Fc heavy chain) and, therefore, can function as a multivalent ligand that complexes with IgE in various conformations depending on the ratio of their molar concentrations (Liu et al., 1995; PMID: 7654701). This antibody has been shown to reduce serum IgE levels and significantly attenuate both the early- and late-phase responses to inhaled allergen in allergic asthmatic subjects (Fahy et al., 1997; PMID: 9196082). Omalizumab treatment has been shown to reduce asthma exacerbations and decrease inhaled corticosteroid and rescue medication use in the treatment of severe allergic asthma (Busse et al., 2001; PMID: 11496232). The therapeutic product made using this antibody (omalizumab) binds to human IgE in blood or membrane-bound IgE on B lymphocytes. Furthermore, omalizumab competes with IgE's high and low-affinity receptors — FcεRI and CD23, respectively — for binding to residues in the CH3 domain. Therefore, it effectively blocks human IgE binding to FcϵRI without stimulating the degranulation of mast cells and basophils, i.e., without triggering a severe, life-threatening anaphylactic reaction (Wright et al., 2015; PMID: 26113483).

Antibody first published in: Liu et al. Characterization of complex formation by humanized anti-IgE monoclonal antibody and monoclonal human IgE Biochemistry. 1995 Aug 22;34(33):10474-82. doi: 10.1021/bi00033a020 PMID:7654701
Note on publication: The original publication characterizes the formation of immune complexes between a humanized anti-IgE monoclonal antibody and IgE, revealing various complex structures and a high-affinity interaction.

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.

Necessary

Always Enabled

Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.

Cookie	Duration	Description
ASP.NET_SessionId	session	Issued by Microsoft's ASP.NET Application, this cookie stores session data during a user's website visit.
cookielawinfo-checkbox-advertisement	1 year	Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Advertisement" category .
cookielawinfo-checkbox-analytics	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional	11 months	The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy	11 months	The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.

Analytics

Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.

Cookie	Duration	Description
_dc_gtm_UA-49047364-1	1 minute	No description
_ga	2 years	The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors.
_gcl_au	3 months	Provided by Google Tag Manager to experiment advertisement efficiency of websites using their services.
_gid	1 day	Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously.
ai_session	30 minutes	This is a unique anonymous session identifier cookie set by Microsoft Application Insights software to gather statistical usage and telemetry data for apps built on the Azure cloud platform.
ai_user	1 year	A unique user identifier cookie, set by Microsoft Application Insights software, that enables counting of the number of users accessing the application over time.

Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.

Cookie	Duration	Description
_uetsid	1 day	Bing Ads sets this cookie to engage with a user that has previously visited the website.
_uetvid	1 year 24 days	Bing Ads sets this cookie to engage with a user that has previously visited the website.
MUID	1 year 24 days	Bing sets this cookie to recognize unique web browsers visiting Microsoft sites. This cookie is used for advertising, site analytics, and other operations.
test_cookie	15 minutes	The test_cookie is set by doubleclick.net and is used to determine if the user's browser supports cookies.