Anti-IL-12RB2 [IL12Rb2#1]

Description:

Recombinant monoclonal antibody to IL-12RB2. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody IL12Rb2#1.

Clone Name:

IL12Rb2#1

Published Application(s):

FACS, inhibition, SPR, ELISA

Published Species Reactivity:

Human

UniProt Accession Number of Target Protein: Q99665

Alternative Name(s) of Target: Interleukin-12 receptor beta-2 chain; IL-12 receptor beta-2; IL12RB2; IL12Rβ2; IL-12 receptor subunit beta-2; IL-12R subunit beta-2; IL-12R-beta-2; IL-12RB2; Interleukin-12 receptor subunit beta-2
Immunogen: The antibody was generated immunizing Llama. A phage display library was constructed from immune tissue. The antibody was selected by panning against the antigen.

Specificity: The antibody is specific for IL-12RB2. Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor.

Application Notes: The specificity of the original format of the antibody was confirmed by ELISA analysis (IC50 value= 4.2 nM). The binding affinity of the nanobody to IL-12RB2 was measured by surface plasmon resonance (Kd= 2.7 nM). The antibody recognised T cells expressing IL-12RB2, as shown by FACS analysis (EC50= 1.8 nM). The antibody could inhibit the IL-12 function and the dependent IFN-γ secretion was measured. (IC50 of IFNγ release T cells D839 = 51 nM) (US20220242958).

Antibody first published in: PMID:

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