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- Ab04371-23.159 Anti-IL-3Ra [55A01]
- Human
- Rabbit IgG-Fc fusion
- Purified
- Ships in 5-6 weeks
- Ab04371-10.159 Anti-IL-3Ra [55A01]
- Human
- Human IgG1-Fc fusion
- Purified
- Ships in 5-6 weeks
Recombinant monoclonal antibody to IL-3Ra. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody 55A01.
UniProt Accession Number of Target Protein: P26951
Alternative Name(s) of Target: CD123; IL3R; IL3RAY; IL3RX; IL3RY; hIL-3Ra; interleukin 3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha
Specificity: This antibody is specific for the alpha subunit of IL-3R
Application Notes: The binding of the original version of this antibody (VHH) to IL3-Ra-expressing viral lipoparticles was characterized in an ELISA (KD 17.1 nM). In a FACS binding assay, this antibody exhibited an EC50 of 8.2 nM, 11 nM, and 1.1 nM for MOLM-13, THP-1, and HEK-IL-R3a, respectively, and an IC50 of 40.0 nM in competition against clone 7G3. In its bi-specific constructions with clones 14D09 and 281F12, it served as an anchor (US20220242958).
Antibody first published in: PMID: Note on publication: The original publication describes the construction and characterization of various bi-specific antibodies.